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ST 2825

Catalog No. T16937Cas No. 894787-30-5

ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 inhibition of IL-1β-mediated activation of NF-κB transcriptional activity.

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Pack Size	Price	Availability
25 mg	$1,970	8-10 weeks
50 mg	$2,580	8-10 weeks
100 mg	$3,400	8-10 weeks

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Product Introduction

Bioactivity

Description	ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 inhibition of IL-1β-mediated activation of NF-κB transcriptional activity.
In vitro	ST2825 blocks IL-1R/TLR signaling by interfering with MyD88 homodimerization. ST2825 inhibits this interaction in a concentration-dependent manner with ~40% inhibition of dimerization at ST2825 (5 μM) and 80% inhibition at ST2825 (10 μM ) [1].
In vivo	ST2825 effectively reduces IL-1β-induced IL-6 production in mice through oral administration, showing significant inhibition at 100 and 200 mg/kg doses. Mice receive oral doses of ST2825 or vehicles, ranging from 50 to 200 mg/kg, five minutes before intraperitoneal (i.p.) injections of 20 μg/kg IL-1β [1].

Chemical Properties

Molecular Weight	591.51
Formula	C27H28Cl2N4O5S
Cas No.	894787-30-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (169.06 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6906 mL	8.4529 mL	16.9059 mL	84.5294 mL
5 mM	0.3381 mL	1.6906 mL	3.3812 mL	16.9059 mL
10 mM	0.1691 mL	0.8453 mL	1.6906 mL	8.4529 mL
20 mM	0.0845 mL	0.4226 mL	0.8453 mL	4.2265 mL
50 mM	0.0338 mL	0.1691 mL	0.3381 mL	1.6906 mL
100 mM	0.0169 mL	0.0845 mL	0.1691 mL	0.8453 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc